General description

CD138, Syndecan 1, is expressed in the late stages of B-cell differentiation with progression towards plasma cells.^1,2 It can be used to differentiate lymphoplasmacytic lymphoma from marginal zone lymphoma.¹ ALK+ large B-cell lyphoma (LBCL) usually strongly expresses CD138 whereas lineage-associated markers such as anti-CD20 and anti-CD79a do not stain ALK+LBCL.^3,7 Anti-CD138 is immunoreactive with HHV8-associated primary effusion lymphoma even though the lymphoma cells lack the expression of B-cell markers.⁵ Anti-CD138 is a good marker to identify and enumerate plasma cells, benign, reactive, or malignant, in bone marrow biopsy specimens.^4,6 CD138 is also expressed in epithelial cells.⁶

Legal Information

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Linkage

CD138 Positive Control Slides, Product No. 138S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

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Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide.

Preparation Note

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Quality